Design, synthesis, and characterization of new cyclic d,l-α-alternate amino acid peptides by capillary electrophoresis coupled to electrospray ionization mass spectrometry. | Semantic Scholar (2024)

This new capillary electrophoresis coupled to electrospray ionization mass spectrometry (CE-ESI-MS) methodology allows verifying the structure, the purity, as well as the stability of interesting potential precursors for PNTs that could be employed as nanoplatforms in diagnostics or pseudo sieving tools for separation purposes.

This review focuses on the synthesis, functionalization and characterization of peptide sequences that can self-assemble to form nanostructures and their main applications in the biomedical field will be presented so as to highlight their importance and advantages over classical nanstructures.

The classification of hyphenated techniques and their roles is discussed in addition to the advantages of chromatographic techniques over the other separation techniques, which can be used for small as well as large-scale separations with good separation efficiency and high accuracy.

The review brings a comprehensive survey of recent developments and applications of high performance capillary and microchip electroseparation methods to analysis, micropreparation, purification, and physicochemical and biochemical characterization of peptides in the years 2013, 2014, and up to the middle of 2015.

This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018, and describes latest developments on hyphenation of CE with MS as well as instrumental developments such as two‐dimensional separation systems with MS detection.

A new class of cyclic peptide foldamers (3alpha,gamma-CPs) that, depending on their backbone N-methylation patterns and the medium, can either remain as flat rings that dimerize through arrays of hydrogen bonds of antiparallel beta-sheet type, or can fold into twisted double reverse turns that associate in nonpolar solvents to form helical supramolecular structures.

The design, synthesis and characterization of a new class of organic nanotubes based on rationally designed cyclic polypeptides are reported, which may have possible applications in inclusion chemistry, catalysis, molecular electronics and molecular separation technology.

It is shown that three parameters are essential for the formation of lanreotide nanotubes: the specificity of two of the three aromatic side chains, the spatial arrangement of the hydrophilic and hydrophobic residues, and the aromatic side chain in the beta-turn of the molecule.

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